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- Title
Rapid in vivo induction of leukocyte tissue factor mRNA and protein synthesis following low dose endotoxin administration to rabbits.
- Authors
Brutzki, T C; Kulczycky, M J; Bardossy, L; Clarke, B J; Blajchman, M A
- Abstract
Disseminated intravascular coagulation in humans is frequently associated with Gram-negative bacterial sepsis. Therefore, to examine the role and time frame of the in vivo induction of tissue factor (TF) by bacterial endotoxin, a reverse transcription polymerase chain reaction and a solid-phase ELISA assay were developed to monitor the in vivo production in rabbits, of TF mRNA and TF antigen by peripheral blood leukocytes (PBL).
- Publication
The hematology journal : the official journal of the European Haematology Association, 2001, Vol 2, Issue 3, p188
- ISSN
1466-4860
- Publication type
Journal Article
- DOI
10.1038/sj.thj.6200088