We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
p16/INK4a gene inactivation by hypermethylation is associated with aggressive variants of monoclonal gammopathies.
- Authors
Mateos, M V; Garcia-Sanz, R; López-Pérez, R; Balanzategui, A; González, M I; Fernández-Calvo, J; Moro, M J; Hernández, J; Caballero, M D; González, M; San Miguel, J F
- Abstract
A model of a stepwise malignant transformation has been proposed for the pathogenesis of monoclonal gammopathies. In this model, cell cycle regulators play a central role as a source of genetic events; particularly, p16/INK4a gene acts as a tumoral suppressor gene and, recently, inactivation of this gene through a methylation mechanism, has been observed in multiple myeloma patients. Under the diagnosis of monoclonal gammopathies there is a broad spectrum of disorders with very different outcomes, ranging from indolent courses, such as those of monoclonal gammopathy of undetermined significance, Waldeströn macroglobulinemia and smoldering multiple myeloma, to aggressive diseases such as symptomatic MM and primary plasma cell leukemia. To the best of our knowledge, the activity of p16 gene has not been evaluated and compared in these different subtypes of monoclonal gammopathies.
- Publication
The hematology journal : the official journal of the European Haematology Association, 2001, Vol 2, Issue 3, p146
- ISSN
1466-4860
- Publication type
Journal Article
- DOI
10.1038/sj.thj.6200084