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- Title
STAT3beta does not interfere with granulocyte colony-stimulating factor-induced neutrophilic differentiation.
- Authors
de Koning, J P; Ward, A C; Caldenhoven, E; de Groot, R P; Löwenberg, B; Touw, I P
- Abstract
Activation of the signal transducer and activator of transcription protein STAT3 is a crucial step in granulocyte colony-stimulating factor (G-CSF)-mediated cell cycle exit and subsequent neutrophilic differentiation of myeloid precursor cells. We have recently demonstrated that this is mediated, at least in part, by upregulation of the cyclin-dependent kinase inhibitor p27(Kip1). The splice variant STAT3beta, that lacks a C-terminal serine residue implicated in the transcriptional activity of STAT3, has been shown to inhibit STAT3-mediated transcription in certain situations. STAT3beta is known to be expressed in hematopoietic cells, but its role in controlling the balance between proliferation and differentiation has not been established.
- Publication
The hematology journal : the official journal of the European Haematology Association, 2000, Vol 1, Issue 4, p220
- ISSN
1466-4860
- Publication type
Journal Article
- DOI
10.1038/sj.thj.6200041