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- Title
Activation and regulation of ATM kinase activity in response to DNA double-strand breaks.
- Authors
Lee, J-H; Paull, T T
- Abstract
The ataxia-telangiectasia-mutated (ATM) protein kinase is rapidly and specifically activated in response to DNA double-strand breaks in eukaryotic cells. In this review, we summarize recent insights into the mechanism of ATM activation, focusing on the role of the Mre11/Rad50/Nbs1 (MRN) complex in this process. We also compare observations of the ATM activation process in different biological systems and highlight potential candidates for cellular factors that may participate in regulating ATM activity in human cells.
- Publication
Oncogene, 2007, Vol 26, Issue 56, p7741
- ISSN
1476-5594
- Publication type
Journal Article
- DOI
10.1038/sj.onc.1210872