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- Title
NF-kappaB and the immune response.
- Authors
Hayden, M S; West, A P; Ghosh, S
- Abstract
One of the primary physiological roles of nuclear factor-kappa B (NF-kappaB) is in the immune system. In particular, NF-kappaB family members control the transcription of cytokines and antimicrobial effectors as well as genes that regulate cellular differentiation, survival and proliferation, thereby regulating various aspects of innate and adaptive immune responses. In addition, NF-kappaB also contributes to the development and survival of the cells and tissues that carry out immune responses in mammals. This review, therefore, describes the role of the NF-kappaB pathway in the development and functioning of the immune system.
- Publication
Oncogene, 2006, Vol 25, Issue 51, p6758
- ISSN
0950-9232
- Publication type
Journal Article
- DOI
10.1038/sj.onc.1209943