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- Title
Identification of RASSF8 as a candidate lung tumor suppressor gene.
- Authors
Falvella, F S; Manenti, G; Spinola, M; Pignatiello, C; Conti, B; Pastorino, U; Dragani, T A
- Abstract
The RASSF8 gene, which maps close to the KRAS2 gene, contains a RAS-associated domain and encodes a protein that is evolutionarily conserved from fish to humans. Analysis of the RASSF8 transcript revealed a complex expression pattern of 5'-UTR mRNA isoforms in normal lung and in lung adenocarcinomas (ADCAs), with no apparent differences. However, RASSF8 gene transcript levels were approximately seven-fold-lower in lung ADCAs as compared to normal lung tissue. Expression of RASSF8 protein by transfected lung cancer cells led to inhibition of anchorage-independent growth in soft agar in A549 cells and reduction of clonogenic activity in NCI-H520 cells. These results raise the possibility protein encoded by RASSF8 is a novel tumor suppressor for lung cancer.
- Publication
Oncogene, 2006, Vol 25, Issue 28, p3934
- ISSN
0950-9232
- Publication type
Journal Article
- DOI
10.1038/sj.onc.1209422