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- Title
Cyclin D1: polymorphism, aberrant splicing and cancer risk.
- Authors
Knudsen, K E; Diehl, J Alan; Haiman, C A; Knudsen, E S
- Abstract
The cyclin D1 proto-oncogene exercises powerful control over the mechanisms that regulate the mitotic cell cycle, and excessive cyclin D1 expression and/or activity is common in human cancers. Although somatic mutations of the cyclin D1 locus are rarely observed, mounting evidence demonstrates that a specific polymorphism of cyclin D1 (G/A870) and a protein product of a potentially related alternate splicing event (cyclin D1b) may influence cancer risk and outcome. Herein, we review the epidemiological and functional literatures that link these alterations of cyclin D1 to human tumor development and progression.
- Publication
Oncogene, 2006, Vol 25, Issue 11, p1620
- ISSN
0950-9232
- Publication type
Journal Article
- DOI
10.1038/sj.onc.1209371