We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling.
- Authors
Taylor, Michael D; Zhang, Xiaoyun; Liu, Ling; Hui, Chi-Chung; Mainprize, Todd G; Scherer, Stephen W; Wainwright, Brandon; Hogg, David; Rutka, James T
- Abstract
Germline mutations of APC in patients with Turcot syndrome (colon cancer and medulloblastoma), was well as somatic mutations of APC, beta-catenin, and Axin in sporadic medulloblastomas (MBs) have shown the importance of WNT signaling in the pathogenesis of MB. A subset of children with MB have germline mutations of SUFU, a known inhibitor of Hedgehog signal transduction. A recent report suggested that murine Sufu can bind beta-catenin, export it from the nucleus, and thereby repress beta-catenin/T-cell factor (Tcf)-mediated transcription. We show that an MB-derived mutant of SUFU has lost the ability to decrease nuclear levels of beta-catenin, and cannot inhibit beta-catenin/Tcf-mediated transcription as compared to wild type SUFU. Our results suggest that loss of function of SUFU results in overactivity of both the Sonic Hedgehog, and the WNT signaling pathways, leading to excessive proliferation and failure to differentiate resulting in MB.
- Publication
Oncogene, 2004, Vol 23, Issue 26, p4577
- ISSN
0950-9232
- Publication type
Journal Article
- DOI
10.1038/sj.onc.1207605