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- Title
Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways.
- Authors
Wenle Xia; Mullin, Robert J.; Keith, Barry R.; Lei-Hua Liu; Hong Ma; Rusnak, David W.; Owens, Gary; Alligood, Krystal J.; Spector, Neil L.
- Abstract
Presents a study which examined the anti-tumor activity of the GW572016 molecule. Inhibition of epidermal growth factor receptor erbB2 tyrosine kinases; Inhibition of the activation of Erk1/2 and AKT, downstream effectors of proliferation and cell survival; Materials and methods; Results and discussion.
- Publication
Oncogene, 2002, Vol 21, Issue 41, p6255
- ISSN
0950-9232
- Publication type
Academic Journal
- DOI
10.1038/sj.onc.1205794