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- Title
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-κB signaling.
- Authors
Tien Kuo, Macus; Liu, Zesheng; Yingjie Wei; Yen-chiu Lin-Lee; Tatebe, Shigeru; Mills, Gordon B.; Unate, Hitoshi
- Abstract
Presents a study that examined the role of 2-acetylaminofluorene in the activation of human multidrug resistance (MDR) 1 gene in human hepatoma and embryonic fibroblast 293 cells. Impact of MDR on cancer chemotherapy; Background on P-glytoproteins; MDR genes in humans; Comparison on the coding regions between human MDR1 and rat mdr1b.
- Publication
Oncogene, 2002, Vol 21, Issue 13, p1945
- ISSN
0950-9232
- Publication type
Academic Journal
- DOI
10.1038/sj.onc.1205117