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- Title
E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis.
- Authors
Polager, Shirley; Kalma, Yael; Berkovich, Eli; Ginsberg, Doron
- Abstract
The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation in higher eukaryotes. We used DNA microarrays and cell lines containing either inducible E2F-1 or inducible E2F-3 to identify novel E2F target genes. Our data indicate that E2F up-regulates the expression of genes not previously described as E2F target genes. A number of these E2F-regulated genes are involved in DNA replication, DNA repair and mitosis. These results suggest that E2F affects cell cycle progression both at S phase and during mitosis. Furthermore, our findings indicate that E2F-dependent gene activation may contribute to the cellular response to DNA damage.
- Publication
Oncogene, 2002, Vol 21, Issue 3, p437
- ISSN
0950-9232
- Publication type
Journal Article
- DOI
10.1038/sj.onc.1205102