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- Title
Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G<sub>2</sub>/M arrest or apoptosis.
- Authors
Yang, Xiaolong; Li, Da-ming; Chen, Weili; Xu, Tian
- Abstract
The lats gene encodes a family of proteins conserved from insects to humans. Drosophila carrying lats mutant cells or mice deficient for Lats1 develop tumors in various tissues. The mammalian LATS1 protein was previously shown to bind to CDC2, suggesting that LATS1 may modulate G2/M cell cycle progression by affecting CDC2 activity. In this study, we introduced human LATS1 into LATS-/- MEF cells by adenovirus-mediated gene transfer. Overexpression of LATS1 causes G2/M arrest through inhibition of CDC2 kinase activity. Furthermore, overexpression of LATS1 significantly suppressed the human tumor cell growth in vitro and tumorigenicity in vivo by inducing either cell cycle arrest in G2/M or apoptosis. These observations suggest that LATS1 is a potent growth suppressor and, like other tumor suppressors, it suppresses growth by inducing cell cycle arrest or apoptosis. Oncogene (2001) 20, 6516–6523.
- Publication
Oncogene, 2001, Vol 20, Issue 45, p6516
- ISSN
0950-9232
- Publication type
Academic Journal
- DOI
10.1038/sj.onc.1204817