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- Title
MEN2A-RET-induced cellular transformation by activation of STAT3.
- Authors
Schuringa, J J; Wojtachnio, K; Hagens, W; Vellenga, E; Buys, C H; Hofstra, R; Kruijer, W
- Abstract
The MEN2A oncogene encodes for a constitutive active member of the RET receptor tyrosine kinase family. Here, we report that MEN2A-RET activates Signal Transducer and Activator of Transcription 3 (STAT3) via two YxxV/Q STAT3 docking sites, Tyr752 and Tyr928. MEN2A-RET induces both Tyr705 and Ser727 phosphorylation of STAT3, and STAT3 serine phosphorylation is required for its maximal transcriptional activity. Stable NIH3T3 cell lines expressing both MEN2A-RET and STAT3alpha but not STAT3beta, are characterized by enhanced proliferation and cyclin-D1 promoter activity, and enhanced growth in soft agar. These data indicate that malignant cell growth induced by MEN2A-RET involves its activation of STAT3.
- Publication
Oncogene, 2001, Vol 20, Issue 38, p5350
- ISSN
0950-9232
- Publication type
Journal Article
- DOI
10.1038/sj.onc.1204715