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- Title
Bcl-2 expression delays mammary tumor development in dimethylbenz(a)anthracene-treated transgenic mice.
- Authors
Murphy, K L; Kittrell, F S; Gay, J P; Jäger, R; Medina, D; Rosen, J M
- Abstract
Bcl-2 is known to have dual antiproliferative and antiapoptotic roles. Overexpression of Bcl-2 in the mammary gland using a whey acidic protein (WAP) promoter-driven Bcl-2 transgene inhibits apoptosis in the mammary gland during pregnancy, lactation, and involution, and also counteracts apoptosis induced by overexpression of a mutant p53 transgene (WAP-p53 172 R-L). WAP-Bcl-2 mice and nontransgenic controls were treated with the carcinogen dimethylbenz(a)anthracene (DMBA). Surprisingly, the nontransgenic mice developed mammary tumors with decreased latency. Tumors arising in WAP-Bcl-2 mice displayed substantially reduced levels of proliferation relative to those seen in nontransgenic mice (P < 0.015), perhaps resulting in the observed increase in tumor latency following carcinogen treatment. This WAP-Bcl-2 mouse tumor model reflects the situation seen in some human breast cancers overexpressing Bcl-2, where expression of Bcl-2 has been shown to correlate with a lower proliferative index in tumors.
- Publication
Oncogene, 1999, Vol 18, Issue 47, p6597
- ISSN
0950-9232
- Publication type
Journal Article
- DOI
10.1038/sj.onc.1203099