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- Title
Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity.
- Authors
Legoix, P; Bluteau, O; Bayer, J; Perret, C; Balabaud, C; Belghiti, J; Franco, D; Thomas, G; Laurent-Puig, P; Zucman-Rossi, J
- Abstract
To determine the frequency of Wnt/Wingless beta catenin pathway alteration in human hepatocellular carcinoma, a beta catenin and APC gene mutation screening was performed in a series of 119 tumors. An activating beta catenin mutation in exon 3 was found in 18% of the cases. Among tumors lacking beta catenin mutation, no APC mutation has been evidenced in a subset of 30 cases tested. The correlation between beta catenin mutation status and chromosome segment deletions was studied on a set of 48 hyperploid tumors. Chromosome 1p, 4q and 16p deletions were significantly associated with the absence of beta catenin mutation (P<0.05). Furthermore the Fractional Allelic Loss was significantly smaller in the beta catenin mutated tumors than in the non-mutated tumors (0.12 versus 022). Taken together, these results suggest, the existence of two carcinogenesis mechanisms. The first mechanism implies a beta catenin activating mutation associated with a low rate of loss of heterozygosity. The second mechanism, operating in a context of chromosomal instability, would involve tumor suppressor genes.
- Publication
Oncogene, 1999, Vol 18, Issue 27, p4044
- ISSN
0950-9232
- Publication type
Journal Article
- DOI
10.1038/sj.onc.1202800