We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inhibition of Bak-induced apoptosis by HPV-18 E6.
- Authors
Thomas, M; Banks, L
- Abstract
Human papillomavirus (HPV) E6 proteins inhibit apoptosis in both p53-dependent and p53-independent manners. A key point in apoptosis is the regulation provided by the Bcl-2 family; and in differentiating keratinocytes, in which HPV replicates, the Bak protein is highly expressed. We show that HPV-18 E6 will inhibit Bak-induced apoptosis and this is mediated by an interaction between the E6 and Bak proteins resulting in degradation of the Bak protein in vivo. We also show that Bak protein interacts with the ubiquitin ligase, E6AP, and that a mutant of Bak defective in E6AP binding is overexpressed in comparison with wild type. These studies suggest that Bak is probably the first naturally occurring target of E6AP to be identified.
- Publication
Oncogene, 1998, Vol 17, Issue 23, p2943
- ISSN
0950-9232
- Publication type
Journal Article
- DOI
10.1038/sj.onc.1202223