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- Title
Fragile X: translation in action.
- Authors
Bear, Mark F; Dölen, Gül; Osterweil, Emily; Nagarajan, Naveen
- Abstract
Fragile X is a synapsopathy--a disorder of synaptic function and plasticity. Recent studies using mouse models of the disease suggest that the critical defect is altered regulation of synaptic protein synthesis. Various strategies to restore balanced synaptic protein synthesis have been remarkably successful in correcting widely varied mutant phenotypes in mice. Insights gained by the study of synaptic plasticity in animal models of fragile X have suggested novel therapeutic approaches, not only for human fragile X but also for autism and mental retardation of unknown etiology.
- Publication
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Vol 33, Issue 1, p84
- ISSN
0893-133X
- Publication type
Journal Article
- DOI
10.1038/sj.npp.1301610