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- Title
Higher 5-HT<sub>1A</sub> Receptor Binding Potential During a Major Depressive Episode Predicts Poor Treatment Response: Preliminary Data from a Naturalistic Study.
- Authors
Parsey, Ramin V.; Olvet, Doreen M.; Oquendo, Maria A.; Yung-yu Huang; Ogden, R. Todd; Mann, J. John
- Abstract
Serotonin 1A (5-HT1A) binding potential (BP) as assessed by positron emission tomography (PET) is higher in major depressive disorder (MDD) in association with the higher expressing GG genotype of the 5-HT1A C-1019G polymorphism. We hypothesize that higher 5-HT1A BP and the GG genotype predict remission failure on antidepressant treatment. We determined 5-HT1A BP by PET and 5-HT1A C-1019G genotype in 43 controls and 22 medication-free MDD subjects. MDD was treated naturalistically and remission was defined as >50% reduction and a score of 10 on the 24 item Hamilton Scale 1 year after initiation of treatment after scanning. Despite equivalent treatment, nonremitters have higher pretreatment cortical BP and the GG genotype is over-represented compared with remitters. Higher 5-HT1A BP, perhaps due to greater gene expression, may predict antidepressant medication nonremission. The findings should be tested in a controlled prospective treatment study.Neuropsychopharmacology (2006) 31, 1745–1749. doi:10.1038/sj.npp.1300992; published online 4 January 2006
- Publication
Neuropsychopharmacology, 2006, Vol 31, Issue 8, p1745
- ISSN
0893-133X
- Publication type
Academic Journal
- DOI
10.1038/sj.npp.1300992