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- Title
Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study.
- Authors
Massat, I; Souery, D; Del-Favero, J; Oruc, L; Noethen, M M; Blackwood, D; Thomson, M; Muir, W; Papadimitriou, G N; Dikeos, D G; Kaneva, R; Serretti, A; Lilli, R; Smeraldi, E; Jakovljevic, M; Folnegovic, V; Rietschel, M; Milanova, V; Valente, F; Van Broeckhoven, C; Mendlewicz, J
- Abstract
The available data from preclinical and pharmacological studies on the role of gamma amino butyric acid (GABA) support the hypothesis that a dysfunction in brain GABAergic system activity contributes to the vulnerability to bipolar affective disorders (BPAD). Moreover, the localization of the alpha3 subunit GABA receptor GABRA3 gene on the Xq28, a region of interest in certain forms of bipolar illness, suggests that GABRA3 may be a candidate gene in BPAD. In the present study, we tested the genetic contribution of the GABRA3 dinucleotide polymorphism in a European multicentric case-control sample, matched for sex and ethnogeographical origin. Allele and genotype (in females) frequencies were compared in 185 BPAD patients and 370 controls. A significant increase of genotype 1-1 was observed in BPAD females compared to controls (P=0.0004). Furthermore, when considering recessivity of allele 1 (females with genotype 1-1 and males carrying allele 1), results were even more significant (P= 0.00002). Our findings suggest that the GABRA3 polymorphism may confer susceptibility to or may be in linkage disequilibrium with another gene involved in the genetic etiology of BPAD.
- Publication
Molecular psychiatry, 2002, Vol 7, Issue 2, p201
- ISSN
1359-4184
- Publication type
Journal Article
- DOI
10.1038/sj.mp.4000953