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- Title
Increased S100B blood levels in unmedicated and treated schizophrenic patients are correlated with negative symptomatology.
- Authors
Rothermundt, M; Missler, U; Arolt, V; Peters, M; Leadbeater, J; Wiesmann, M; Rudolf, S; Wandinger, K P; Kirchner, H
- Abstract
S100B, a calcium-binding protein produced by astroglial cells, is a marker of astroglial cellular integrity. It has been shown to be increased in acute brain damage and neurodegeneration. A recent study showed increased S100B levels in medicated acutely psychotic patients with schizophrenia. The study presented here included 26 drug-free patients with acute schizophrenia and 26 matched healthy controls. S100B blood concentrations were determined using a quantitative immunoassay upon admission and after 6 weeks of neuroleptic treatment. The PANSS was used to investigate psychopathology. Unmedicated schizophrenic patients showed significantly increased S100B levels compared to matched healthy controls. After 6 weeks of treatment, 11 patients showed normal S100B levels while in 15 patients the levels remained increased. These patients showed significantly higher PANSS negative scores upon admission and after 6 weeks of treatment. Schizophrenic patients display a loss of astroglial integrity which is not caused by neuroleptic medication. Continuously increased S100B levels are associated with negative symptomatology.
- Publication
Molecular psychiatry, 2001, Vol 6, Issue 4, p445
- ISSN
1359-4184
- Publication type
Journal Article
- DOI
10.1038/sj.mp.4000889