We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data.
- Authors
van der Velden, V H J; Cazzaniga, G; Schrauder, A; Hancock, J; Bader, P; Panzer-Grumayer, E R; Flohr, T; Sutton, R; Cave, H; Madsen, H O; Cayuela, J M; Trka, J; Eckert, C; Foroni, L; Zur Stadt, U; Beldjord, K; Raff, T; van der Schoot, C E; van Dongen, J J M; European Study Group on MRD detection in ALL (ESG-MRD-ALL)
- Abstract
Most modern treatment protocols for acute lymphoblastic leukaemia (ALL) include the analysis of minimal residual disease (MRD). To ensure comparable MRD results between different MRD-polymerase chain reaction (PCR) laboratories, standardization and quality control are essential. The European Study Group on MRD detection in ALL (ESG-MRD-ALL), consisting of 30 MRD-PCR laboratories worldwide, has developed guidelines for the interpretation of real-time quantitative PCR-based MRD data. The application of these guidelines ensures identical interpretation of MRD data between different laboratories of the same MRD-based clinical protocol. Furthermore, the ESG-MRD-ALL guidelines will facilitate the comparison of MRD data obtained in different treatment protocols, including those with new drugs.
- Publication
Leukemia, 2007, Vol 21, Issue 4, p604
- ISSN
0887-6924
- Publication type
Journal Article
- DOI
10.1038/sj.leu.2404586