We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Human cord blood long-term engrafting cells are CD34<sup>+</sup> CD38<sup>-</sup>.
- Authors
Ishikawa, F; Livingston, A G; Minamiguchi, H; Wingard, J R; Ogawa, M
- Abstract
There have been controversies about CD34 and CD38 expression by human cord blood (CB) stem cells. Using the newborn NOD/SCID/β2-microglobulin-null mouse assay that we recently developed, we examined the in vivo engrafting capability of human CB cells. Almost all of the 4-5 months engrafting cells were found in CD34[SUP+] population. The capability of secondary reconstitution was found only in the CD34[SUP+] cells. When the CD34[SUP+]CB cells were separated into CD38[SUP-] and CD38[SUP+] subpopulations and tested for engraftment, the majority of the engrafting cells were detected in the CD38[SUP-] subpopulation. These findings are consistent with the results from studies of murine stem cells and strongly indicate that the phenotype of human CB stem cells is CD34[SUP+]CD38[SUP-].
- Publication
Leukemia (08876924), 2003, Vol 17, Issue 5, p960
- ISSN
0887-6924
- Publication type
Academic Journal
- DOI
10.1038/sj.leu.2402878