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- Title
Phenotypic transformation of CD52<sup>pos</sup> to CD52<sup>neg</sup> leukemic T cells as a mechanism for resistance to CAMPATH-1H.
- Authors
Birhiray, R E; Shaw, G; Guldan, S; Rudolf, D; Delmastro, D; Santabarbara, P; Brettman, L
- Abstract
Immunotherapy utilizing CAMPATH-1H for patients with chemotherapy-refractory chronic lymphocytic leukemia has yielded encouraging results with many reports of complete remission. Here we report the outcome of two patients with CD4-positive T cell prolymphocytic leukemia treated with CAM-PATH-1H. Both patients responded rapidly to treatment and subsequently developed CD4 lymphopenia. One patient remained in complete remission after 14 weeks of treatment. Serial peripheral blood flow cytometry revealed that the CD52 antigen was present throughout treatment. The other patient who was initially CD52-positive, became CD52-negative after 6 weeks of treatment, and developed progressive symptoms of T cell prolymphocytic leukemia. Immunotherapy was stopped, chemotherapy proved futile, and the patient died. This change in phenotype from CD52-positive to -negative during CAM-PATH-1H therapy points out a need to develop strategies for maintaining antigenic expression during monoclonal antibody therapy.
- Publication
Leukemia (08876924), 2002, Vol 16, Issue 5, p861
- ISSN
0887-6924
- Publication type
Academic Journal
- DOI
10.1038/sj.leu.2402471