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- Title
Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients.
- Authors
Suki, W N; Zabaneh, R; Cangiano, J L; Reed, J; Fischer, D; Garrett, L; Ling, B N; Chasan-Taber, S; Dillon, M A; Blair, A T; Burke, S K
- Abstract
Elevated serum phosphorus and calcium are associated with arterial calcification and mortality in dialysis patients. Unlike calcium-based binders, sevelamer attenuates arterial calcification but it is unknown whether sevelamer affects mortality or morbidity. In a multicenter, randomized, open-label, parallel design trial we compared sevelamer and calcium-based binders on all-cause and cause-specific mortality (cardiovascular, infection, and other) in prevalent hemodialysis patients. A total of 2103 patients were initially randomized to treatment and 1068 patients completed the study. All-cause mortality rates and cause-specific mortality rates were not significantly different. There was a significant age interaction on the treatment effect. Only in patients over 65 years of age was there a significant effect of sevelamer in lowering the mortality rate. There was a suggestion that sevelamer was associated with lower overall, but not cardiovascular-linked, mortality in older patients. We suggest that further research is needed to confirm these findings.
- Publication
Kidney international, 2007, Vol 72, Issue 9, p1130
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1038/sj.ki.5002466