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- Title
P-glycoprotein and bilirubin disposition.
- Authors
Watchko, J F; Daood, M J; Mahmood, B; Vats, K; Hart, C; Ahdab-Barmada, M
- Abstract
P-glycoprotein (Pgp), an ATP-dependent plasma membrane efflux pump, is expressed in abundance on the luminal aspect of brain capillary endothelial cells and astrocytes of the blood-brain barrier where it limits the passage of a variety of lipophilic substrates into the central nervous system. This review summarizes current evidence characterizing (1) unconjugated bilirubin as a potential substrate for Pgp and (2) the ontogeny of Pgp expression at the blood-brain barrier and apical brush border epithelium of the gastrointestinal tract, findings that may provide insights regarding the disposition of bilirubin in immature subjects.
- Publication
Journal of perinatology : official journal of the California Perinatal Association, 2001, Vol 21 Suppl 1, pS43
- ISSN
0743-8346
- Publication type
Journal Article
- DOI
10.1038/sj.jp.7210633