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- Title
Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells.
- Authors
Lowes, Michelle A; Kikuchi, Toyoko; Fuentes-Duculan, Judilyn; Cardinale, Irma; Zaba, Lisa C; Haider, Asifa S; Bowman, Edward P; Krueger, James G
- Abstract
The importance of T helper 17 (Th17) cells in inflammation and autoimmunity is now being appreciated. We analyzed psoriasis skin lesions and peripheral blood for the presence of IL-17-producing T cells. We localized Th17 cells predominantly to the dermis of psoriasis skin lesions, confirmed that IL-17 mRNA increased with disease activity, and demonstrated that IL-17 mRNA expression normalized with cyclosporine therapy. IL-22 mRNA expression mirrored IL-17 and both were downregulated in parallel with keratin 16. Th17 cells are a discrete population, separate from Th1 cells (which are also in psoriasis lesions), and Th2 cells. Our findings suggest that psoriasis is a mixed Th1 and Th17 inflammatory environment. Th17 cells may be proximal regulators of psoriatic skin inflammation, and warrant further attention as therapeutic targets.
- Publication
The Journal of investigative dermatology, 2008, Vol 128, Issue 5, p1207
- ISSN
1523-1747
- Publication type
Journal Article
- DOI
10.1038/sj.jid.5701213