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- Title
Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma.
- Authors
Li, Chunying; Liu, Zhensheng; Zhang, Zhengdong; Strom, Sara S; Gershenwald, Jeffrey E; Prieto, Victor G; Lee, Jeffrey E; Ross, Merrick I; Mansfield, Paul F; Cormier, Janice N; Duvic, Madeleine; Grimm, Elizabeth A; Wei, Qingyi
- Abstract
Sunlight causes DNA damage but also induces production of vitamin D whose metabolite 1,25-(OH)2D3 has antiproliferative and pro-differentiative effects in both melanocytes and cutaneous melanoma (CM) cells mediated through the vitamin D receptor (VDR). We hypothesized that genetic polymorphisms of VDR are associated with risk of CM. In a hospital-based case-control study of 602 non-Hispanic white CM patients and 603 cancer-free control subjects frequency matched by age and sex, we genotyped two VDR polymorphisms (TaqI and FokI) and assessed their association with CM risk. We found that a significantly decreased risk was associated with VDR-TaqI Tt (adjusted odds ratio (OR), 0.70; 95% confidence interval (CI), 0.54-0.90) and Tt+tt (OR=0.70; 95% CI, 0.55-0.89) genotypes, compared with the VDR-TaqI TT genotype, whereas an increased risk was associated with VDR-FokI Ff genotype (OR=1.32; 95% CI, 1.03-1.68), and a borderline significantly increased risk was associated with Ff+ff (OR=1.26; 95% CI, 1.00-1.59) genotypes, compared with the VDR-FokI FF genotype. In conclusion, genetic variants (i.e., TaqI t protective allele and FokI f risk allele) in VDR may alter risk of CM.
- Publication
The Journal of investigative dermatology, 2007, Vol 127, Issue 2, p276
- ISSN
1523-1747
- Publication type
Journal Article
- DOI
10.1038/sj.jid.5700544