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- Title
More than one gene involved in monilethrix: intracellular but also extracellular players.
- Authors
Schweizer, Jurgen
- Abstract
Monilethrix, an autosomal dominant human hair disorder, is caused by mutations in three type II hair cortex keratins. Rare cases of the disease with non-vertical transmission have now been found to overlap with localized autosomal recessive hypotrichosis. The underlying gene, desmoglein 4 (DSG4), belongs to the desmosomal cadherin superfamily and is also expressed in the cortex of the hair follicle.
- Publication
The Journal of investigative dermatology, 2006, Vol 126, Issue 6, p1216
- ISSN
0022-202X
- Publication type
Journal Article
- DOI
10.1038/sj.jid.5700266