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- Title
Kit and melanocyte migration.
- Authors
Grichnik, James M
- Abstract
As described in this issue, Alexeev and Yoon introduced a Kit-activating mutation into melanocytes. Although mitogenic in mast cells, this mutation was motogenic in melanocytes. Further, melanocytes had a reduced proliferative rate and were less differentiated. The disparate response may be due to differences in the cellular milieu of melanocytes and may have implications for normal melanocytic integration into the epidermis, nevogenesis, and melanoma.
- Publication
The Journal of investigative dermatology, 2006, Vol 126, Issue 5, p945
- ISSN
0022-202X
- Publication type
Journal Article
- DOI
10.1038/sj.jid.5700164