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- Title
Distinct Clinical Differences Between HLA-Cw<sup>*</sup>0602 Positive and Negative Psoriasis Patients – An Analysis of 1019 HLA-C- and HLA-B-Typed Patients.
- Authors
Gudjonsson, Johann E.; Karason, Ari; Runarsdottir, E. Hjaltey; Antonsdottir, Arna A.; Hauksson, Valdimar B.; Jónsson, Hjörtur H.; Gulcher, Jeff; Stefansson, Kari; Valdimarsson, Helgi
- Abstract
A major susceptibility gene for psoriasis is located in the major histocompatibility complex class I region on chromosome 6 very close to the HLA-Cw6 gene. We collected a cohort of 1,019 patients with chronic plaque psoriasis. The patients were typed for HLA-C and HLA-B. A total of 654 (64.2%) were HLA-Cw*0602 positive but 365 (35.8%) carried other HLA-C alleles. We confirmed that HLA-Cw*0602 positive patients have younger age of onset (17.5 vs 24.3 years, P<10−10), higher incidence of guttate and the eruptive type of psoriasis (P<0.0001), more frequent exacerbations with throat infections (P=0.01), higher incidence of the Koebner's phenomenon (P=0.01), and more extensive disease (P=0.03). A striking new finding was a diverging pattern of disease severity in HLA-Cw*0602 positive and negative patients depending on the age of onset of the disease (P=0.0006). HLA-Cw*0602 positive women also had more frequent remissions during pregnancy (P<0.0001). All types of nail changes were, however, more common in the Cw*0602 negative patients (P=0.003) and they more often had multiple types of nail lesions (P<0.0001). The three ancestral haplotypes of Cw*0602 all conferred an increase in odds ratio but showed no difference in any of the clinical features studied. Our findings indicate that the genetic factor on chromosome 6 has a strong influence on the phenotype of the disease, and underline that differences in clinical features of psoriasis may be to a large extent genetically determined.Journal of Investigative Dermatology (2006) 126, 740–745. doi:10.1038/sj.jid.5700118; published online 26 January 2006
- Publication
Journal of Investigative Dermatology, 2006, Vol 126, Issue 4, p740
- ISSN
0022-202X
- Publication type
Academic Journal
- DOI
10.1038/sj.jid.5700118