We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Reverse dosimetry: interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling.
- Authors
Yu-Mei Tan; Liao, Kai H.; Clewell, Harvey J.
- Abstract
Biomonitoring data provide evidence of exposure of environmental chemicals but are not, by themselves, direct measures of exposure. To use biomonitoring data in understanding exposure, physiologically based pharmacokinetic (PBPK) modeling can be used in a reverse dosimetry approach to assess a distribution of exposures possibly associated with specific blood or urine levels of compounds. Reverse dosimetry integrates PBPK modeling with exposure pattern characterization, Monte Carlo analysis, and statistical tools to estimate a distribution of exposures that are consistent with biomonitoring data in a population. The present study used an existing PBPK model for chloroform as a generic framework to develop PBPK models for other trihalomethanes (THMs). Using Monte Carlo sampling techniques, probabilistic information about pharmacokinetics and exposure patterns was included to estimate distributions of THMs concentrations in blood in relation to various exposure patterns in a diverse population. In addition, the possibility of inhibition of hepatic metabolism among THMs was evaluated under the scenarios of household exposure. These studies demonstrated how PBPK modeling can be used as a tool to estimate a population distribution of exposures that could have resulted in particular biomonitoring results. When toxicity level is known, this tool can also be used to estimate proportion of population above levels associated with health risk.Journal of Exposure Science and Environmental Epidemiology (2007) 17, 591–603; doi:10.1038/sj.jes.7500540; published online 15 November 2006
- Publication
Journal of Exposure Science & Environmental Epidemiology, 2007, Vol 17, Issue 7, p591
- ISSN
1559-0631
- Publication type
Academic Journal
- DOI
10.1038/sj.jes.7500540