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- Title
The chromosome cycle: coordinating replication and segregation. Second in the cycles review series.
- Authors
Blow, J Julian; Tanaka, Tomoyuki U
- Abstract
During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.
- Publication
EMBO reports, 2005, Vol 6, Issue 11, p1028
- ISSN
1469-221X
- Publication type
Journal Article
- DOI
10.1038/sj.embor.7400557