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- Title
Plexin-B3 is a functional receptor for semaphorin 5A.
- Authors
Artigiani, Stefania; Conrotto, Paolo; Fazzari, Pietro; Gilestro, Giorgio F; Barberis, Davide; Giordano, Silvia; Comoglio, Paolo M; Tamagnone, Luca
- Abstract
Semaphorins are a large family of molecular cues implicated in neural development and in a variety of functions outside the nervous system. Semaphorin 5A (Sema5A) is a transmembrane semaphorin, containing seven thrombospondin type-1 repeats, which was recently found to control axon guidance. Here we show that plexin-B3 is a high-affinity receptor specific for Sema5A. We further demonstrate that plexin-B3 activation by Sema5A mediates functional responses in plexin-B3-expressing cells (either fibroblasts, epithelial and primary endothelial cells). In addition, Sema5A can trigger the intracellular signalling of the hepatocyte growth factor/scatter factor receptor, Met, associated in a complex with plexin-B3. We thus conclude that Sema5A is able to elicit multiple functional responses through its receptor plexin-B3.
- Publication
EMBO reports, 2004, Vol 5, Issue 7, p710
- ISSN
1469-221X
- Publication type
Journal Article
- DOI
10.1038/sj.embor.7400189