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- Title
LIP-1 phosphatase controls the extent of germline proliferation in Caenorhabditis elegans.
- Authors
Myon-Hee Lee; Brad Hook; Lamont, Liana B.; Wickens, Marvin; Kimble, Judith
- Abstract
Caenorhabditis elegans germline cells are maintained in an undifferentiated and mitotically dividing state by Notch signaling and the FBF (for fem-3 binding factor) RNA-binding protein. Here, we report that the LIP-1 phosphatase, a proposed homolog of mitogen-activated protein (MAP) kinase phosphatases, is required for the normal extent of germline proliferation, and that lip-1 controls germline proliferation by regulating MAP kinase activity. In wild-type germ lines, LIP-1 protein is present in the proximal third of the mitotic region, consistent with its effect on germline proliferation. We provide evidence that lip-1 expression in the germline mitotic region is controlled by a combination of GLP-1/Notch signaling and FBF repression. Unexpectedly, FBF controls the accumulation of lip-1 mRNA, and therefore is likely to control its stability or 3′-end formation. In a sensitized mutant background, LIP-1 can function as a pivotal regulator of the decision between proliferation and differentiation. The control of germline proliferation by LIP-1 has intriguing parallels with the control of stem cells and progenitor cells in vertebrates.
- Publication
EMBO Journal, 2006, Vol 25, Issue 1, p88
- ISSN
0261-4189
- Publication type
Academic Journal
- DOI
10.1038/sj.emboj.7600901