We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK.
- Authors
Unterseher, Frank; Hefele, Joerg A; Giehl, Klaudia; De Robertis, Eddy M; Wedlich, Doris; Schambony, Alexandra
- Abstract
Convergent extension movements occur ubiquitously in animal development. This special type of cell movement is controlled by the Wnt/planar cell polarity (PCP) pathway. Here we show that Xenopus paraxial protocadherin (XPAPC) functionally interacts with the Wnt/PCP pathway in the control of convergence and extension (CE) movements in Xenopus laevis. XPAPC functions as a signalling molecule that coordinates cell polarity of the involuting mesoderm in mediolateral orientation and thus selectively promotes convergence in CE movements. XPAPC signals through the small GTPases Rho A and Rac 1 and c-jun N-terminal kinase (JNK). Loss of XPAPC function blocks Rho A-mediated JNK activation. Despite common downstream components, XPAPC and Wnt/PCP signalling are not redundant, and the activity of both, XPAPC and PCP signalling, is required to coordinate CE movements.
- Publication
The EMBO journal, 2004, Vol 23, Issue 16, p3259
- ISSN
0261-4189
- Publication type
Journal Article
- DOI
10.1038/sj.emboj.7600332