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- Title
Defective downregulation of receptor tyrosine kinases in cancer.
- Authors
Bache, Kristi G; Slagsvold, Thomas; Stenmark, Harald
- Abstract
Most growth factors control cellular functions by activating specific receptor tyrosine kinases (RTKs). While overactivation of RTK signalling pathways is strongly associated with carcinogenesis, it is becoming increasingly clear that impaired deactivation of RTKs may also be a mechanism in cancer. A major deactivation pathway, receptor downregulation, involves ligand-induced endocytosis of the RTK and subsequent degradation in lysosomes. A complex molecular machinery that uses the small protein ubiquitin as a key regulator assures proper endocytosis and degradation of RTKs. Here we discuss evidence that implicates deregulation of this machinery in cancer.
- Publication
The EMBO journal, 2004, Vol 23, Issue 14, p2707
- ISSN
0261-4189
- Publication type
Journal Article
- DOI
10.1038/sj.emboj.7600292