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- Title
JunD regulates lymphocyte proliferation and T helper cell cytokine expression.
- Authors
Meixner, Arabella; Karreth, Florian; Kenner, Lukas; Wagner, Erwin F
- Abstract
Transgenic mice broadly expressing JunD (Ubi-junD(m)) appear phenotypically normal, but have strongly reduced numbers of peripheral lymphocytes. JunD overexpression in lymphocytes does not protect from numerous apoptotic insults; however, transgenic T cells proliferate poorly and exhibit impaired activation due to reduced levels of IL-4, CD25 and CD69. Consistently, in the absence of JunD (junD(-/-)) T cells hyperproliferate following mitogen induction. Moreover, transgenic T helper (Th) 2 cells have decreased IL-4 and IL-10 expression, whereas junD(-/-) Th2 cells secrete higher amounts of both Th2 cytokines. Th1-polarized junD(-/-) CD4(+) T cells display enhanced IFN-gamma cytokine production associated with upregulated T-bet expression and downregulated expression of suppressor of cytokine signaling-1. These novel findings demonstrate a regulatory role of JunD in T lymphocyte proliferation and Th cell differentiation.
- Publication
The EMBO journal, 2004, Vol 23, Issue 6, p1325
- ISSN
0261-4189
- Publication type
Journal Article
- DOI
10.1038/sj.emboj.7600133