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- Title
Molecular evidence for absence of Y-linkage of the Hairy Ears trait.
- Authors
Lee, Andrew C; Kamalam, Angamuthu; Adams, Susan M; Jobling, Mark A
- Abstract
The human Hairy Ears phenotype has traditionally been regarded as the only Y-linked heritable trait. Here, we use Y-chromosomal DNA binary-marker haplotyping to show that a cohort of southern Indian Hairy-Eared males carries Y chromosomes from many haplogroups of the Y-phylogeny, which, under a hypothesis of Y linkage, would require multiple independent mutations within a single population. We further show that there is no significant difference between the Y-haplogroup spectrum in Hairy-Eared males and that in a geographically matched control sample of unaffected males. The trait cannot, therefore, be Y-linked in southern Indians, and by extension, is unlikely to be so in any population.
- Publication
European journal of human genetics : EJHG, 2004, Vol 12, Issue 12, p1077
- ISSN
1018-4813
- Publication type
Journal Article
- DOI
10.1038/sj.ejhg.5201271