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- Title
Effect of lycopene supplementation on insulin-like growth factor-1 and insulin-like growth factor binding protein-3: a double-blind, placebo-controlled trial.
- Authors
Graydon, R; Gilchrist, S E C M; Young, I S; Obermüller-Jevic, U; Hasselwander, O; Woodside, J V
- Abstract
Studies have suggested a link between lycopene and insulin-like growth factor-1 (IGF-1). The aim of this study was to test the effect of lycopene supplementation on IGF-1 and binding protein-3 (IGFBP-3) status in healthy male volunteers. DESIGN, SETTING, SUBJECTS AND INTERVENTION: This was a 4 week randomized, double-blind, placebo-controlled study of lycopene supplementation (15 mg/day) in healthy male volunteers (n=20). Fasting blood samples were collected at baseline and after 4 weeks. Samples were analysed for lycopene by high-performance liquid chromatography (HPLC) and IGF-1 and IGFBP-3 by enzyme-linked immunosorbent assay (ELISA). Changes in end points from baseline were compared in those who received placebo versus those who received the lycopene supplement.
- Publication
European journal of clinical nutrition, 2007, Vol 61, Issue 10, p1196
- ISSN
0954-3007
- Publication type
Journal Article
- DOI
10.1038/sj.ejcn.1602632