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- Title
The mitochondrial serine protease HtrA2/Omi: an overview.
- Authors
Walle, L. Vande; Lamkanfi, M.; Vandenabeele, P.
- Abstract
The HtrA family refers to a group of related oligomeric serine proteases that combine a trypsin-like protease domain with at least one PDZ interaction domain. Mammals encode four HtrA proteases, named HtrA1–4. The protease activity of the HtrA member HtrA2/Omi is required for mitochondrial homeostasis in mice and humans and inactivating mutations associated with neurodegenerative disorders such as Parkinson's disease. Moreover, HtrA2/Omi is released in the cytosol, where it contributes to apoptosis through both caspase-dependent and -independent pathways. Here, we review the current knowledge of HtrA2/Omi biology and discuss the signaling pathways that underlie its mitochondrial and apoptotic functions from an evolutionary perspective.Cell Death and Differentiation (2008) 15, 453–460; doi:10.1038/sj.cdd.4402291; published online 4 January 2008
- Publication
Cell Death & Differentiation, 2008, Vol 15, Issue 3, p453
- ISSN
1350-9047
- Publication type
Academic Journal
- DOI
10.1038/sj.cdd.4402291