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- Title
Caspase substrates.
- Authors
Timmer, J C; Salvesen, G S
- Abstract
The relatively common occurrence of sequences within proteins that match the consensus substrate specificity of caspases in intracellular proteins suggests a multitude of substrates in vivo - somewhere in the order of several hundred in humans alone. Indeed, the list of proteins that are reported to be cleaved by caspases in vitro proliferates rapidly. However, only a few of these proteins have been rigorously established as biologically or pathologically relevant, bona fide substrates in vivo. Many of them probably simply represent 'innocent bystanders' or erroneous assignments. In this review we discuss concepts of caspase substrate recognition and specificity, give resources for the discovery and annotation of caspase substrates, and highlight some specific human or mouse proteins where there is strong evidence for biologic or pathologic relevance.
- Publication
Cell death and differentiation, 2007, Vol 14, Issue 1, p66
- ISSN
1350-9047
- Publication type
Journal Article
- DOI
10.1038/sj.cdd.4402059