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- Title
Stem cell transplantation for neuroblastoma.
- Authors
Fish, J D; Grupp, S A
- Abstract
High-risk neuroblastoma is a childhood malignancy with a poor prognosis. Gradual improvements in survival have correlated with therapeutic intensity, and the ability to harvest, process and store autologous hematopoietic stem cells has allowed for dose intensification beyond marrow tolerance. The use of high-dose chemotherapy with autologous hematopoietic stem cell rescue in consolidation has resulted in improvements in survival, although further advances are still needed. Newer approaches to SCT and supportive care, most notably the transition to PBSC, have resulted in further improvement in survival and decreases in treatment-related mortality. Research into experimental approaches to hematopoietic SCT is ongoing.
- Publication
Bone marrow transplantation, 2008, Vol 41, Issue 2, p159
- ISSN
0268-3369
- Publication type
Journal Article
- DOI
10.1038/sj.bmt.1705929