We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Long-term outcomes in children with high-risk neuroblastoma treated with autologous stem cell transplantation.
- Authors
Trahair, T N; Vowels, M R; Johnston, K; Cohn, R J; Russell, S J; Neville, K A; Carroll, S; Marshall, G M
- Abstract
We retrospectively analysed the outcomes of children transplanted for high-risk neuroblastoma (NB) at a single institution predominantly transplanted with total body irradiation and chemotherapy. The aims of this study were to determine the prognostic impact of clinical and biological features and to document long-term health outcomes. Forty patients were transplanted with a single unpurged autograft. Fourteen patients died from disease progression and two from late complications of treatment. Twenty-three patients are alive at a median of 4.6 years from diagnosis. Kaplan-Meier estimates of overall survival at 2, 5 and 10 years are 76+/-7.0, 60.2+/-8.4 and 54.7+/-9.3% following transplant. Response to induction therapy was significantly associated with survival (P<0.01). Long-term complications included growth (100%) and pubertal failure (83%), hearing impairment (73%), orthopaedic complications (63%), renal impairment (47%) and thyroid abnormalities (36%). Intrinsic and acquired resistance to chemotherapy remains the major obstacle to improving outcomes in high-risk NB. Although patients with chemo-sensitive disease are less likely to experience a relapse, substantial therapy-related toxicities result in poor long-term health outcomes for survivors.
- Publication
Bone marrow transplantation, 2007, Vol 40, Issue 8, p741
- ISSN
0268-3369
- Publication type
Journal Article
- DOI
10.1038/sj.bmt.1705809