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- Title
Liver failure complicating non-alcoholic steatohepatitis following allogeneic bone marrow transplantation for Shwachman-Diamond syndrome.
- Authors
Ritchie, D S; Angus, P W; Bhathal, P S; Grigg, A P
- Abstract
Bone marrow transplantation is potentially curative therapy for the hematologic complications associated with Shwachman-Diamond syndrome (SDS). This syndrome is, however, also associated with significant pancreatic and hepatic dysfunction, which may complicate BMT. We report a case of liver failure due to non-alcoholic steatohepatitis (NASH) following BMT for SDS. This case illustrates the need for assessing liver dysfunction pre-BMT in these patients, in addition to highlighting the potential risk posed by pre-existing steatosis for the development of rapidly progressive hepatic failure following transplantation.
- Publication
Bone marrow transplantation, 2002, Vol 29, Issue 11, p931
- ISSN
0268-3369
- Publication type
Journal Article
- DOI
10.1038/sj.bmt.1703549