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- Title
The flavonoid luteolin inhibits niacin-induced flush.
- Authors
Papaliodis, D; Boucher, W; Kempuraj, D; Theoharides, T C
- Abstract
Sustained release niacin effectively lowers serum cholesterol, LDL and triglycerides, while raising HDL. However, 75% of patients experience cutaneous warmth and itching known as flush, leading to discontinuation. Acetylsalicylic acid (aspirin) reduces this flush only by about 30%, presumably through decreasing prostaglandin D2 (PGD2). We investigated whether niacin-induced flush in a rat model involves PGD2 and 5-HT, and the effect of certain flavonoids.
- Publication
British journal of pharmacology, 2008, Vol 153, Issue 7, p1382
- ISSN
0007-1188
- Publication type
Journal Article
- DOI
10.1038/sj.bjp.0707668