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- Title
Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism.
- Authors
Sun, Y; Alexander, S P H; Garle, M J; Gibson, C L; Hewitt, K; Murphy, S P; Kendall, D A; Bennett, A J
- Abstract
Although CB(1) receptor activation evokes neuroprotection in response to cannabinoids, some cannabinoids have been reported to be peroxisome proliferator activated receptor (PPAR) ligands, offering an alternative protective mechanism. We have, therefore, investigated the ability of a range of cannabinoids to activate PPAR alpha and for N-oleoylethanolamine (OEA), an endogenous cannabinoid-like compound (ECL), to evoke neuroprotection.
- Publication
British journal of pharmacology, 2007, Vol 152, Issue 5, p734
- ISSN
0007-1188
- Publication type
Journal Article
- DOI
10.1038/sj.bjp.0707478