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Title
The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase products.
Authors
Fischer, L; Hornig, M; Pergola, C; Meindl, N; Franke, L; Tanrikulu, Y; Dodt, G; Schneider, G; Steinhilber, D; Werz, O
Abstract
Licofelone is a dual inhibitor of the cyclooxygenase and 5-lipoxygenase (5-LO) pathway, and has been developed for the treatment of inflammatory diseases. Here, we investigated the molecular mechanisms underlying the inhibition by licofelone of the formation of 5-LO products.
Publication
British journal of pharmacology, 2007, Vol 152, Issue 4, p471