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- Title
Post-ischemic treatment with erythropoietin or carbamylated erythropoietin reduces infarction and improves neurological outcome in a rat model of focal cerebral ischemia.
- Authors
Wang, Y; Zhang, Z G; Rhodes, K; Renzi, M; Zhang, R L; Kapke, A; Lu, M; Pool, C; Heavner, G; Chopp, M
- Abstract
Recombinant human erythropoietin (rhEPO; Epoetin-alpha; PROCRITtrade mark) has been shown to exert neuroprotective and restorative effects in a variety of CNS injury models. However, limited information is available regarding the dose levels required for these beneficial effects or the neuronal responses that may underlie them. Here we have investigated the dose-response to rhEPO and compared the effects of rhEPO with those of carbamylated rhEPO (CEPO) in a model of cerebral stroke in rats.
- Publication
British journal of pharmacology, 2007, Vol 151, Issue 8, p1377
- ISSN
0007-1188
- Publication type
Journal Article
- DOI
10.1038/sj.bjp.0707285