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- Title
Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3.
- Authors
Cleton-Jansen, A M; Moerland, E W; Pronk, J C; van Berkel, C G; Apostolou, S; Crawford, J; Savoia, A; Auerbach, A D; Mathew, C G; Callen, D F; Cornelisse, C J
- Abstract
The recently identified Fanconi anaemia A (FAA) gene is located on chromosomal band 16q24.3 within a region that has been frequently reported to show loss of heterozygosity (LOH) in breast cancer. FAA mutation analysis of 19 breast tumours with specific LOH at 16q24.3 was performed. Single-stranded conformational polymorphism (SSCP) analysis on cDNA and genomic DNA, and Southern blotting failed to identify any tumour-specific mutations. Five polymorphisms were identified, but frequencies of occurrence did not deviate from those in a normal control population. Therefore, the FAA gene is not the gene targeted by LOH at 16q24.3 in breast cancer. Another tumour suppressor gene in this chromosomal region remains to be identified.
- Publication
British journal of cancer, 1999, Vol 79, Issue 7-8, p1049
- ISSN
0007-0920
- Publication type
Journal Article
- DOI
10.1038/sj.bjc.6690168