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- Title
Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells.
- Authors
Chakraborty, S; Kanakasabai, S; Bright, J J
- Abstract
Brain tumours present unique challenges to conventional therapies and pose major health problems around the world. Brain tumour stem cells (BTSCs) represent a small fraction of tumour cells that maintain growth, drug resistance and recurrence properties. Constitutive androstane receptor (CAR) is a nuclear receptor transcription factor that regulates drug metabolism and homoeostasis. In this study, we examined the effect of CAR agonist, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehydeO-(3,4-dichlorobenzyl)oxime (CITCO) on BTSCs.
- Publication
British journal of cancer, 2011, Vol 104, Issue 3, p448
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/sj.bjc.6606064